Understand depression, calmly and clearly.
Plain-language, evidence-based explanations of what depression is, why it happens, how it's treated, and where to find help — for yourself or someone you love.
10 topics100 articlesEvidence-basedFree & ad-free
Symptoms & Signs
8 articles- Symptoms Over Syndromes: Why the Pieces Matter More Than the Label7 min
- Anhedonia: The Loss of Pleasure and Interest7 min
- Motivation, Avolition, and Apathy: When the Drive to Act Fails6 min
- Fatigue: The Exhaustion That Outlasts Rest6 min
- Brain Fog: Cognitive Symptoms and the Clouded Mind6 min
Causes & Mechanisms
22 articles- The Pathophysiology of Depression (Overview)12 min
- Monoaminergic Dysfunction in Depression10 min
- Neuroplasticity, BDNF, and Neurotrophic Deficits in Depression9 min
- HPA-Axis Dysregulation in Depression12 min
- Chronic Stress and Allostatic Load in Depression9 min
Diagnosis
5 articlesTreatment & Therapy
12 articles- The Psychotherapies: A Guide to the Landscape9 min
- Cognitive Behavioral Therapy (CBT)24 min
- Dialectical Behavior Therapy (DBT)19 min
- Mindfulness-Based Cognitive Therapy (MBCT)19 min
- Psychodynamic Psychotherapy20 min
Medications
11 articles- Psychiatric Medications — A Clinical Guide to the Landscape12 min
- Serotonergic Psychiatric Medications29 min
- Tricyclic Antidepressants and MAOIs14 min
- Glutamatergic and Rapid-Acting Agents in Psychiatry18 min
- GABAergic Agents14 min
Interventions
7 articles- Interventional and Neurostimulation Psychiatry (Overview)9 min
- Electroconvulsive Therapy (ECT)7 min
- Transcranial Magnetic Stimulation (TMS)7 min
- Transcranial Direct Current Stimulation (tDCS)6 min
- Focused Ultrasound and Ablative Neurosurgery6 min
Supplements
11 articles- Nutraceutical Psychiatry: A Critical Synthesis10 min
- Omega-3 Fatty Acids (EPA/DHA)8 min
- Vitamin D7 min
- Magnesium4 min
- Zinc3 min
Philosophy
13 articlesAll 13 in PhilosophyLiterature
10 articles- Literature and Melancholy5 min
- Robert Burton7 min
- Samuel Johnson7 min
- Emily Dickinson8 min
- Fyodor Dostoevsky7 min
Religion
1 articleDepression is not a sign of weakness. It is a medical condition, and with the right support, it can improve.