Antipsychotics for Depression
Antipsychotic medications are increasingly used in the treatment of depression, particularly for treatment-resistant depression or when depressive symptoms include psychotic features. They are often used as add-on therapy alongside antidepressants.
Atypical Antipsychotics Used for Depression
Second-generation antipsychotics approved as adjunct treatments for major depressive disorder include aripiprazole (Abilify), quetiapine (Seroquel), brexpiprazole (Rexulti), and olanzapine-fluoxetine combination (Symbyax).
How They Work
Atypical antipsychotics work on multiple neurotransmitter systems, including dopamine and serotonin receptors. Their broad receptor activity can enhance the effects of antidepressants, reduce anxiety, improve sleep, and address symptoms that antidepressants alone may not fully control.
Side Effects and Monitoring
Common side effects include weight gain, metabolic changes, sedation, and movement-related side effects. Regular monitoring by a healthcare provider is important when taking antipsychotic medications long-term.
Disclaimer: This page is for informational purposes only. Always consult a qualified healthcare provider before starting, changing, or stopping any medication.